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Inhibited and Uninhibited Infants "Grown Up": Adult Amygdalar Response to Novelty
Carl E. Schwartz,1,2,3*
Christopher I. Wright,2,3,4
Lisa M. Shin,2,5
Jerome Kagan,6
Scott L. Rauch2,3
Abstract:
Infants with an inhibited temperament tend to develop into childrenwho avoid people, objects, and situations that are novel orunfamiliar, whereas uninhibited children spontaneously approachnovel persons, objects, and situations. Behavioral and physiologicalfeatures of these two temperamental categories are moderatelystable from infancy into early adolescence and have been hypothesizedto be due, in part, to variation in amygdalar responses to novelty.We found that adults who had been categorized in the secondyear of life as inhibited, compared with those previously categorizedas uninhibited, showed greater functional MRI signal responsewithin the amygdala to novel versus familiar faces.
1 Developmental Psychopathology Research Group, Department of Psychiatry, Massachusetts General Hospital (MGH), Harvard Medical School, 13th Street, Building 149, CNY-9, Charlestown, MA 02129, USA. 2 Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital (MGH), Harvard Medical School, 13th Street, Building 149, CNY-9, Charlestown, MA 02129, USA. 3 Athinoula A. Martinos Center for Biomedical Imaging, and Nuclear Magnetic Resonance Center, MGH, Charlestown, MA 02129, USA. 4 Brigham Behavioral Neurology Group, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. 5 Department of Psychology, Tufts University, Medford, MA 02155, USA. 6 Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
* To whom correspondence should be addressed. E-mail: carl_schwartz{at}hms.harvard.edu
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