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Science 289 (5480): 765-768

Copyright © 2000 by the American Association for the Advancement of Science

CikA, a Bacteriophytochrome That Resets the Cyanobacterial Circadian Clock

Oliver Schmitz,1* Mitsunori Katayama,12 Stanly B. Williams,1 Takao Kondo,2 Susan S. Golden1dagger

The circadian oscillator of the cyanobacterium Synechococcus elongatus, like those in eukaryotes, is entrained by environmental cues. Inactivation of the gene cikA (circadian input kinase) shortens the circadian period of gene expression rhythms in S. elongatus by approximately 2 hours, changes the phasing of a subset of rhythms, and nearly abolishes resetting of phase by a pulse of darkness. The CikA protein sequence reveals that it is a divergent bacteriophytochrome with characteristic histidine protein kinase motifs and a cryptic response regulator motif. CikA is likely a key component of a pathway that provides environmental input to the circadian oscillator in S. elongatus.

1 Department of Biology, Texas A&M University, College Station, TX 77843-3258, USA.
2 Division of Biological Science, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
*   Present address: Botanisches Institut, University of Cologne, Gyrhofstrasse 15, 50931 Cologne, Germany.

dagger    To whom correspondence should be addressed. E-mail: sgolden{at}tamu.edu

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