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Science 285 (5435): 1929-1931

Copyright © 1999 by the American Association for the Advancement of Science

Acute Activation of Maxi-K Channels (hSlo) by Estradiol Binding to the beta  Subunit

Miguel A. Valverde, 1* Patricio Rojas, 2 Julio Amigo, 2 Diego Cosmelli, 2 Patricio Orio, 2 Maria I. Bahamonde, 2 Giovanni E. Mann, 4 Cecilia Vergara, 2 Ramon Latorre 23

Maxi-K channels consist of a pore-forming alpha  subunit and a regulatory beta  subunit, which confers the channel with a higher Ca2+ sensitivity. Estradiol bound to the beta  subunit and activated the Maxi-K channel (hSlo) only when both alpha  and beta  subunits were present. This activation was independent of the generation of intracellular signals and could be triggered by estradiol conjugated to a membrane-impenetrable carrier protein. This study documents the direct interaction of a hormone with a voltage-gated channel subunit and provides the molecular mechanism for the modulation of vascular smooth muscle Maxi-K channels by estrogens.

1 Departament de Ciències Experimentals i de la Salut, Universidad Pompeu Fabra, C/Doctor Aiguader 80, 08003 Barcelona, Spain.
2 Departmento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile, and Centro de Estudios Cientificos de Santiago, Casilla 16443, Santiago 9, Chile.
3 Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA 90095-1778, USA.
4 Centre for Cardiovascular Biology and Medicine, School of Biomedical Sciences, King's College London, London SE1 9RT, UK.
*   To whom correspondence should be addressed. E-mail: miguel.valverde{at}cexs.upf.es

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